Daily life-threatening respiratory melancholy and Loss of life have occurred in children who received codeine. A lot of the described cases happened pursuing tonsillectomy and/or adenoidectomy and many of the children had proof of currently being extremely-swift metabolizers of codeine due to a cytochrome P450 (CYP) 2D6 polymorphism (see WARNINGS, https://wockusa.com/product/4-aco-det/