Chemotherapy was potentiated by E7449 and one agent experienced sizeable antitumor exercise in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, very likely as a result of TNKS inhibition. In line with this risk, E7449 stabilized axin and TNKS proteins resulting in β-catenin https://lindseye196vad9.scrappingwiki.com/user